In The Wild | Mixlab Blog

Caring for Equine Influenza: Tips & Treatments for Your Horse

Written by Admin | May 22, 2025

Equine influenza can significantly impact your horse's health. Beyond causing discomfort and illness, an outbreak can sideline your horse from competitions and events—disrupting training schedules and competitive goals. While some horses may carry the equine influenza virus without exhibiting symptoms, others can experience a range of effects from mild lethargy to severe respiratory distress. Knowing how to properly care for your infected horse can ensure their swift and complete recovery.

What is Equine Influenza?

Equine influenza is a respiratory infection caused by strains of the influenza A virus that are adapted to horses. Equine influenza is primarily caused by two subtypes of the influenza A virus, identified by the proteins hemagglutinin (H) and neuraminidase (N) on its surface. Hemagglutinin (H) helps the virus attach to and enter your horse’s cells, while neuraminidase (N) enables it to spread to other horses. The most common cause of  equine influenza outbreaks is the H3N8 subtype.

The equine influenza virus is notorious for its ability to mutate and evolve. In fact, there are 198 possible combinations of H and N subtypes, made from 18 different “H” subtypes and 11 “N” subtypes. Through a process called antigenic drift, genetic changes accumulate over time, sometimes leading to new strains that evade your horse's immune system. Since your horse’s immune system does not recognize the traits of these new strains, they can lead to more severe illness or even become fatal. These gradual genetic changes have led to specific strains of equine influenza that now commonly affect horses in the United States and Europe. Currently, New Zealand and Iceland do not have equine influenza.

Is Equine Influenza Contagious?

Yes, equine influenza is highly contagious and can spread rapidly, primarily through respiratory droplets when an infected horse coughs, sneezes, or even exhales. Infected horses can shed the virus for up to 14 days, and a single cough can propel the virus up to 150 feet, facilitating swift transmission among nearby horses, especially in environments where horses are housed together. Implementing strict biosecurity measures—such as handwashing, disinfecting, wearing personal protective equipment (PPE), modifying delivery protocols and more—can also help contain the spread during an outbreak.

How Horses Become Infected with Equine Influenza

Horses can contract equine influenza from a variety of sources and situations, such as:

  • Large Gatherings of Horses: Shows, races, competitions and other events where horses congregate in close proximity provide an ideal environment for an outbreak. Shared water with infected horses can also spread equine influenza.
  • Infected Equipment: The virus can survive on surfaces, making contaminated tack, grooming tools, feed buckets and even human clothing potential sources of transmission.
  • Human Interaction: Handlers and caretakers who have been in contact with infected horses can inadvertently transfer the virus to healthy horses through their hands, clothing or equipment.
  • Asymptomatic Carriers: Some horses may harbor the virus without showing any equine influenza symptoms, unknowingly spreading the virus and posing a risk to others.

The virus tends to be more prevalent during colder months. Additionally, horses recovering from equine influenza are susceptible to secondary infections, such as bacterial pneumonia, particularly within the first few weeks post-infection.

How to Recognize Equine Influenza Symptoms

Early detection of equine influenza can mitigate its impact and prevent further spread. After your horse is exposed to the virus, you will likely notice symptoms 3-5 days later. The worst symptoms usually last a few days. Horses with a mild case of equine influenza will recover from their illness within a few weeks.

Younger horses, aged 1-5 years old, are most vulnerable to infection with the virus. Additionally, horses whose training or traveling schedules suppress their immune systems are more susceptible to equine influenza. Even if your horse does not have a high risk, you should keep an eye out for these common equine influenza symptoms:

  • Cough: A dry, hacking cough is often the first sign of equine influenza. Even when all other symptoms subside, some horses still have a cough for up to six weeks.
  • Fever: Look out for an elevated body temperature, sometimes reaching up to 106°F.
  • Nasal Discharge: Clear discharge from the nostrils is a sign that something is up. If your horse develops a secondary infection, the discharge may turn yellow or white.
  • Lethargy and Weakness: A typically active horse might suddenly have a noticeable drop in energy levels and be reluctant to engage in their usual activities. This fatigue can also be accompanied by muscle pain.
  • Loss of Appetite: It's not uncommon for horses with influenza to eat and drink less than usual, which can raise concerns about dehydration or weight loss if it persists.
  • Enlarged Lymph Nodes: Lymph nodes in the neck and head area may become larger in size and slightly painful to the touch.

Very severe cases of equine influenza, though rare, could result in impaired heart function (cardiomyopathy) or lower leg swelling (distal limb edema). If your horse exhibits any of these equine influenza symptoms, you should consult with your veterinarian as soon as possible for a diagnosis and treatment plan.

Exploring Available Equine Influenza Treatments

Currently, there is no specific antiviral treatment for equine influenza. However, with appropriate supportive care, rest and a treatment plan from their veterinarians, most horses recover fully. Your veterinarian will likely confirm the presence of the virus by testing a swab from your horse’s nose or throat, known as a RT-PCR array test that detects and measures equine influenza. Other diagnostic tests might include viral isolation, rapid tests or serology.

Your veterinarian may recommend these treatments:

  • Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): If your horse's fever exceeds 104°F, NSAIDs may be prescribed to reduce fever and alleviate discomfort. Mixlab can fill the following NSAID prescriptions to support your horse with equine influenza:
    • Phenylbutazone: 
      • Oral Powder: phenylbutazone 1 gm/scoop + cimetidine 500 mg/scoop, 120 scoop, 5 cc scoop
      • Oral Paste: phenylbutazone 200 mg/mL + cimetidine 100 mg/mL, 60 mL syringe
    • Flunixin meglumine:
      • Oral Powder: flunixin meglumine 500 mg/5 cc scoop, 120 cc scoops
      • Oral Paste: flunixin meglumine 50 mg/mL + Cimetidine 100 mg/mL, 30 mL or 60 mL tube
      • Injectable Solution: Banamine (flunixin meglumine) 50 mg/mL, 100 mL or 250 mL
      • Injectable Solution: Prevail (flunixin meglumine) 50 mg/mL, 100 mL or 250 mL
  • Antibiotics: While antibiotics are ineffective against viruses, they may be necessary if secondary bacterial infections, such as pneumonia, develop. Doxycycline is a commonly prescribed medication in such cases, available at Mixlab in the following forms:
    • Oral Powder: doxycycline hyclate 5 gm/scoop, 20, 30 or 60 cc scoop
    • Oral Paste: doxycycline hyclate 5 g/15 mL, 60 mL
    • Oral Suspension: doxycycline hyclate 100 mg/mL (1,000 mL)

How to Support Your Horse with Equine Influenza

During your horse’s recovery, offering proper care and attention can improve their well-being and reduce the risk of secondary infections. Plus, there are proactive measures you can take to prevent future infections or stop the virus from spreading.

Rest

Give your horse plenty of time to rest and recover. A general guideline is to allow one week of rest for each day your horse has a fever, giving their respiratory system enough time to heal. For most cases of equine influenza, you should give your horse at least three weeks for rest after recovering. In severe cases, extended rest periods of up to six months may be necessary.

Vaccination

Preventative vaccination is the most effective strategy against equine influenza. Collaborate with your veterinarian to establish a vaccination schedule aligned with the American Association of Equine Practitioners (AAEP) recommendations. If your horse does still contract the virus, the vaccination often results in milder symptoms and shorter virus shedding periods.

Monitoring

Consider regularly monitoring your horse's temperature to detect early signs of illness. If your horse is recovering from equine influenza, you should vigilantly watch your horse to see whether symptoms change or worsen. This could indicate more severe illness or the development of a secondary infection, both of which could require medication.

Isolation

To prevent the spread of the virus, isolate your infected horses from healthy ones. Similarly, any new horses arriving at your barn should undergo a quarantine period to ensure they’re not carriers of the virus.

Nutrition

Proper nutrition can support your horse's immune system during recovery from equine influenza. Providing high-quality hay, such as alfalfa, can supply your horse with the necessary nutrients, protein and energy they need. Plus, make sure your hose has access to fresh, clean water at all times.

Care for Your Horse with Mixlab's Equine Pharmacy

We understand the challenges of managing equine influenza and are committed to supporting your horse's health. Our equine pharmacy offers both branded and generic medications to help alleviate equine influenza symptoms and potential secondary conditions. Plus, Mixlab offers compounded antibiotics that suit your horse's preferences and needs. All medications include free, two-day delivery. Submit your prescription online or reach out to our team for help.